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KMID : 1007520110200061649
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Food Science and Biotechnology
2011 Volume.20 No. 6 p.1649 ~ p.1653
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Suppressive Effects of Red Ginseng Preparations on SW480 Colon Cancer Xenografts in Mice
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Yang Go-Eun
Park Dong-Sun
Lee Jin-soo
Song Byeng-Sub
Jeon Tae-Hwan
Kang Shin-Jyung
Jeon Jeong-Hee
Shin Sun-hee
Jeong Heon-Sang
Lee Hwa-Jeong
Kim Yun-Bae
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Abstract
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Anti-tumor efficacies of a red ginseng preparation (RGP) and a cytolase-treated red ginseng preparation (Cytolase-RGP) in an in vitro cytotoxicity assay and in nude mice xenografted with human colon adenocarcinoma (SW480) cells were investigated. The immune-enhancing effect of the preparations was also assessed using a carbonclearance test. The concentrations of protopanaxadiols (including Rb1) and protopanaxatriols (including Rg3) were much higher (1.42-3.43-fold) in Cytolase-RGP than in RGP. RGP and Cytolase-RGP were cytotoxic in vitro to SW480 in a dose-dependent manner, exhibiting IC50 values of 255 and 1,090 μg/mL, respectively. In vivo, the 4-week application of 300 mg/kg RGP or Cytolase-RGP suppressed tumor growth in tumor-bearing mice, decreasing the tumor weight and volume by 15.6-19.3 and 24.4-27.1%, respectively. In the carbon-clearance assay, a 7-day treatment of RGP or Cytolase-RGP at a dose of 300 mg/kg enhanced the phagocytic index of blood macrophages by 307 and 402% of control value, respectively. The results suggest that Cytolase-RGP is superior to RGP in SW480 tumorsuppressive efficacy, and that the increased antitumor activity of Cytolase-RGP might be due to the improved immunomodulatory activity, rather than due to any increase in the cytotoxic activity.
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KEYWORD
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red ginseng preparation, anti-tumor activity, colon cancer, immunomodulation
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